2-(2-{[2-(2-hydroxyethoxy)ethyl]amino}ethoxy)ethan-1-ol
NH-bis-PEG2
CAS: 54384-47-3
Molecular Formula: C8H19NO4
2-(2-{[2-(2-hydroxyethoxy)ethyl]amino}ethoxy)ethan-1-ol - Names and Identifiers
| Name | NH-bis-PEG2 |
| Synonyms | NH-bis-PEG2 NH-(PEG1-OH)2 NH-bis(PEG1-OH) Ethanol, 2,2'-[iminobis(2,1-ethanediyloxy)]bis- 2-(2-{[2-(2-hydroxyethoxy)ethyl]amino}ethoxy)ethan-1-ol |
| CAS | 54384-47-3 |
2-(2-{[2-(2-hydroxyethoxy)ethyl]amino}ethoxy)ethan-1-ol - Physico-chemical Properties
| Molecular Formula | C8H19NO4 |
| Molar Mass | 193.24 |
| Density | 1.090±0.06 g/cm3(Predicted) |
| Boling Point | 128 °C(Press: 0.02 Torr) |
| pKa | 14.09±0.10(Predicted) |
| Storage Condition | 2-8°C，干燥，密封 |
| MDL | MFCD00239212 |
| In vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
2-(2-{[2-(2-hydroxyethoxy)ethyl]amino}ethoxy)ethan-1-ol - Reference Information
| bioactivity | NH-bis-PEG2 is a non-cleavable 2-unit PEG ADC linker, for the synthesis of antibody drug conjugates (ADCs). NH-bis-PEG2 is also a PEG-based PROTAC linker and can be used in the synthesis of PROTAC. |
Last Update：2024-04-09 20:52:54
![2-(2-{[2-(2-hydroxyethoxy)ethyl]amino}ethoxy)ethan-1-ol](http://res.chembk.com/assets/str/2d/5/54/54384-47-3.png)